Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities
Identifieur interne : 000687 ( Main/Exploration ); précédent : 000686; suivant : 000688Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities
Auteurs : Sergio Qui Ones-Parra [Australie] ; Emma Grant [Australie] ; Liyen Loh [Australie] ; Thi H. O. Nguyen [Australie] ; Kristy-Anne Campbell [Australie] ; Steven Y. C. Tong [Australie] ; Adrian Miller [Australie] ; Peter C. Doherty [Australie, États-Unis] ; Dhanasekaran Vijaykrishna ; Jamie Rossjohn [Australie, Royaume-Uni] ; Stephanie Gras [Australie] ; Katherine Kedzierska [Australie]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2014.
Abstract
The severity of the novel H7N9 influenza A virus (IAV) and the lack of neutralizing antibodies raise real pandemic concerns. In this scenario, CD8+ T lymphocytes (CTLs) may provide a layer of protection against the H7N9 virus. Our study dissects the extent of preexisting CTL immunity with the potential to respond to H7N9. We identified conserved immunogenic peptides with the capacity to elicit robust CTL responses against any human IAV, including the H7N9 virus, as well as the mutations that abolish CTL recognition. The human leukocyte antigen class I molecules that present these peptides vary in prevalence depending on the ethnicity. Such analyses found that the Alaskan and Australian Indigenous people may be particularly vulnerable to the H7N9 influenza disease.
Url:
DOI: 10.1073/pnas.1322229111
PubMed: 24395804
PubMed Central: 3903243
Affiliations:
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Nguyen</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medicine, Central Clinical School, The Alfred Centre, Monash University, Melbourne, VIC 3004, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, Central Clinical School, The Alfred Centre, Monash University, Melbourne, VIC 3004</wicri:regionArea><wicri:noRegion>VIC 3004</wicri:noRegion></affiliation></author><author><name sortKey="Campbell, Kristy Anne" sort="Campbell, Kristy Anne" uniqKey="Campbell K" first="Kristy-Anne" last="Campbell">Kristy-Anne Campbell</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800</wicri:regionArea><wicri:noRegion>VIC 3800</wicri:noRegion></affiliation></author><author><name sortKey="Tong, Steven Y C" sort="Tong, Steven Y C" uniqKey="Tong S" first="Steven Y. 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Tong</name><affiliation wicri:level="1"><nlm:aff id="aff4">Menzies School of Health and Research, Charles Darwin University, Causarina, NT 0811, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies School of Health and Research, Charles Darwin University, Causarina, NT 0811</wicri:regionArea><wicri:noRegion>NT 0811</wicri:noRegion></affiliation></author><author><name sortKey="Miller, Adrian" sort="Miller, Adrian" uniqKey="Miller A" first="Adrian" last="Miller">Adrian Miller</name><affiliation wicri:level="1"><nlm:aff id="aff5">Indigenous Research Network, Griffith University, Brisbane, QLD 4111, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Indigenous Research Network, Griffith University, Brisbane, QLD 4111</wicri:regionArea><wicri:noRegion>QLD 4111</wicri:noRegion></affiliation></author><author><name sortKey="Doherty, Peter C" sort="Doherty, Peter C" uniqKey="Doherty P" first="Peter C." last="Doherty">Peter C. Doherty</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff6">Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Immunology, St. Jude Children’s Research Hospital, 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3800</wicri:regionArea><wicri:noRegion>VIC 3800</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8">Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN</wicri:regionArea><wicri:noRegion>Cardiff CF14 4XN</wicri:noRegion></affiliation></author><author><name sortKey="Gras, Stephanie" sort="Gras, Stephanie" uniqKey="Gras S" first="Stephanie" last="Gras">Stephanie Gras</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800</wicri:regionArea><wicri:noRegion>VIC 3800</wicri:noRegion></affiliation></author><author><name sortKey="Kedzierska, Katherine" sort="Kedzierska, Katherine" uniqKey="Kedzierska K" first="Katherine" last="Kedzierska">Katherine Kedzierska</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24395804</idno><idno type="pmc">3903243</idno><idno 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type="main">Preexisting CD8<sup>+</sup> T-cell immunity to the H7N9 influenza A virus varies across ethnicities</title><author><name sortKey="Qui Ones Parra, Sergio" sort="Qui Ones Parra, Sergio" uniqKey="Qui Ones Parra S" first="Sergio" last="Qui Ones-Parra">Sergio Qui Ones-Parra</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Grant, Emma" sort="Grant, Emma" uniqKey="Grant E" first="Emma" last="Grant">Emma Grant</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Loh, Liyen" sort="Loh, Liyen" uniqKey="Loh L" first="Liyen" last="Loh">Liyen Loh</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Nguyen, Thi H O" sort="Nguyen, Thi H O" uniqKey="Nguyen T" first="Thi H. O." last="Nguyen">Thi H. O. Nguyen</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medicine, Central Clinical School, The Alfred Centre, Monash University, Melbourne, VIC 3004, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, Central Clinical School, The Alfred Centre, Monash University, Melbourne, VIC 3004</wicri:regionArea><wicri:noRegion>VIC 3004</wicri:noRegion></affiliation></author><author><name sortKey="Campbell, Kristy Anne" sort="Campbell, Kristy Anne" uniqKey="Campbell K" first="Kristy-Anne" last="Campbell">Kristy-Anne Campbell</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800</wicri:regionArea><wicri:noRegion>VIC 3800</wicri:noRegion></affiliation></author><author><name sortKey="Tong, Steven Y C" sort="Tong, Steven Y C" uniqKey="Tong S" first="Steven Y. C." last="Tong">Steven Y. C. Tong</name><affiliation wicri:level="1"><nlm:aff id="aff4">Menzies School of Health and Research, Charles Darwin University, Causarina, NT 0811, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies School of Health and Research, Charles Darwin University, Causarina, NT 0811</wicri:regionArea><wicri:noRegion>NT 0811</wicri:noRegion></affiliation></author><author><name sortKey="Miller, Adrian" sort="Miller, Adrian" uniqKey="Miller A" first="Adrian" last="Miller">Adrian Miller</name><affiliation wicri:level="1"><nlm:aff id="aff5">Indigenous Research Network, Griffith University, Brisbane, QLD 4111, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Indigenous Research Network, Griffith University, Brisbane, QLD 4111</wicri:regionArea><wicri:noRegion>QLD 4111</wicri:noRegion></affiliation></author><author><name sortKey="Doherty, Peter C" sort="Doherty, Peter C" uniqKey="Doherty P" first="Peter C." last="Doherty">Peter C. Doherty</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff6">Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Immunology, St. Jude Children’s Research Hospital, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Vijaykrishna, Dhanasekaran" sort="Vijaykrishna, Dhanasekaran" uniqKey="Vijaykrishna D" first="Dhanasekaran" last="Vijaykrishna">Dhanasekaran Vijaykrishna</name><affiliation><nlm:aff wicri:cut="; and" id="aff7">Laboratory of Virus Evolution, Program in Emerging Infectious Diseases, Duke–National University of Singapore Graduate Medical School, Republic of Singapore 169857</nlm:aff><wicri:noCountry code="subfield">Republic of Singapore 169857</wicri:noCountry></affiliation></author><author><name sortKey="Rossjohn, Jamie" sort="Rossjohn, Jamie" uniqKey="Rossjohn J" first="Jamie" last="Rossjohn">Jamie Rossjohn</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800</wicri:regionArea><wicri:noRegion>VIC 3800</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8">Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN</wicri:regionArea><wicri:noRegion>Cardiff CF14 4XN</wicri:noRegion></affiliation></author><author><name sortKey="Gras, Stephanie" sort="Gras, Stephanie" uniqKey="Gras S" first="Stephanie" last="Gras">Stephanie Gras</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800</wicri:regionArea><wicri:noRegion>VIC 3800</wicri:noRegion></affiliation></author><author><name sortKey="Kedzierska, Katherine" sort="Kedzierska, Katherine" uniqKey="Kedzierska K" first="Katherine" last="Kedzierska">Katherine Kedzierska</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Victoria, 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>The severity of the novel H7N9 influenza A virus (IAV) and the lack of neutralizing antibodies raise real pandemic concerns. In this scenario, CD8<sup>+</sup> T lymphocytes (CTLs) may provide a layer of protection against the H7N9 virus. Our study dissects the extent of preexisting CTL immunity with the potential to respond to H7N9. We identified conserved immunogenic peptides with the capacity to elicit robust CTL responses against any human IAV, including the H7N9 virus, as well as the mutations that abolish CTL recognition. The human leukocyte antigen class I molecules that present these peptides vary in prevalence depending on the ethnicity. Such analyses found that the Alaskan and Australian Indigenous people may be particularly vulnerable to the H7N9 influenza disease.</p></div></front></TEI><affiliations><list><country><li>Australie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Tennessee</li><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><noCountry><name sortKey="Vijaykrishna, Dhanasekaran" sort="Vijaykrishna, Dhanasekaran" uniqKey="Vijaykrishna D" first="Dhanasekaran" last="Vijaykrishna">Dhanasekaran Vijaykrishna</name></noCountry><country name="Australie"><region name="Victoria (État)"><name sortKey="Qui Ones Parra, Sergio" sort="Qui Ones Parra, Sergio" uniqKey="Qui Ones Parra S" first="Sergio" last="Qui Ones-Parra">Sergio Qui Ones-Parra</name></region><name sortKey="Campbell, Kristy Anne" sort="Campbell, Kristy Anne" uniqKey="Campbell K" first="Kristy-Anne" last="Campbell">Kristy-Anne Campbell</name><name sortKey="Doherty, Peter C" sort="Doherty, Peter C" uniqKey="Doherty P" first="Peter C." last="Doherty">Peter C. Doherty</name><name sortKey="Grant, Emma" sort="Grant, Emma" uniqKey="Grant E" first="Emma" last="Grant">Emma Grant</name><name sortKey="Gras, Stephanie" sort="Gras, Stephanie" uniqKey="Gras S" first="Stephanie" last="Gras">Stephanie Gras</name><name sortKey="Kedzierska, Katherine" sort="Kedzierska, Katherine" uniqKey="Kedzierska K" first="Katherine" last="Kedzierska">Katherine Kedzierska</name><name sortKey="Loh, Liyen" sort="Loh, Liyen" uniqKey="Loh L" first="Liyen" last="Loh">Liyen Loh</name><name sortKey="Miller, Adrian" sort="Miller, Adrian" uniqKey="Miller A" first="Adrian" last="Miller">Adrian Miller</name><name sortKey="Nguyen, Thi H O" sort="Nguyen, Thi H O" uniqKey="Nguyen T" first="Thi H. O." last="Nguyen">Thi H. O. Nguyen</name><name sortKey="Nguyen, Thi H O" sort="Nguyen, Thi H O" uniqKey="Nguyen T" first="Thi H. O." last="Nguyen">Thi H. O. Nguyen</name><name sortKey="Rossjohn, Jamie" sort="Rossjohn, Jamie" uniqKey="Rossjohn J" first="Jamie" last="Rossjohn">Jamie Rossjohn</name><name sortKey="Tong, Steven Y C" sort="Tong, Steven Y C" uniqKey="Tong S" first="Steven Y. C." last="Tong">Steven Y. C. Tong</name></country><country name="États-Unis"><region name="Tennessee"><name sortKey="Doherty, Peter C" sort="Doherty, Peter C" uniqKey="Doherty P" first="Peter C." last="Doherty">Peter C. Doherty</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Rossjohn, Jamie" sort="Rossjohn, Jamie" uniqKey="Rossjohn J" first="Jamie" last="Rossjohn">Jamie Rossjohn</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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